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2,6-二氯甲苯的合成
我公司現(xiàn)在用2-氨基-6-氯甲苯重氮化合成的,成本偏高,我們想用甲苯或鄰氯甲苯直接合成,有沒有可能把成本降到3萬以內,現(xiàn)在有沒有可行的成熟技術.
咨詢者：劉興度 咨詢時間：2008-03-25 狀態(tài)：已回復
專家 中國化工網(wǎng)客服 解答表達感謝 繼續(xù)咨詢該問題 參與討論-
for preparing 2,6-dichlorotoluene. Chlorine gas was bubbled into a molten mixture of 4-toluenesulfonyl chloride (20 g., 105 mM) and antimony trichloride (100 mg, 4 mM) at such a rate as to maintain a reaction temperature of 80.degree. C. When the theoretical amount of chlorine has been taken up, 75% aqueous sulfuric acid (50 mL) was added to the reaction mixture. The resulting dark solution was heated at 130.degree. C. for 40 hours and poured into water (100 mL). This aqueous mixture was neutralized by the slow addition of ammonium hydroxide, followed by ether extraction. The ether extracts were washed with water and brine, dried over anhydrous sodium sulfate and distilled at reduced pressure to give 2,6-dichlorotoluene (8.4 g, 50 wt. %).
yfzhang8888@163.com
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回復：中國化工網(wǎng)客服 回復時間：2008-03-26
留言 08-03-26 09:08 回復者:熱心網(wǎng)友咨詢 表達感謝-
A mixture of 2,6-dichloro-4-toluenesulfonyl chloride (4 g, 15.5 mM) and 75% aqueous sulfuric acid (10 mL) was heated at 130.degree. C. for 40 hours. The reaction mixture was cooled and extracted with toluene. The toluene extracts were washed first with 5% aqueous sodium hydroxide, followed by water and finally brine. Distillation of the toluene left a residue which did not contain 2,6-dichlorotoluene.
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